In this presentation, we will address a variety of those important factors which need to be taken into account when considering the injection molding of compounds based on natural, cellulose-based fillers in thermoplastic matrices. As well, we will examine the major hurdles to be overcome when molding these materials, and offer some insight into how this can be done. Differences in the various species of filler will be briefly discussed, and some of the more important factors to be considered in compounding these materials, as well as during the overall molding process will be addressed. A comparison of the effects on melt index, made by various filler compositions, will be presented.