The use of High Speed Energy Input (HSEI) co-rotating and counter-rotating twin-screw extruders has become the method of choice for processing many biobased polymer compounds. Applications include compounding, reactive processing, devolatilization, and foaming. The final product can be pellets for subsequent forming processes or a direct extrusion of fiber/film/sheet or profile. Recent design enhancements to the HSEI twin-screw extruder offer the benefits of higher torque, improved heat transfer (cooling), and more free volume. This presentation will compare the traditional HSEI twin-screw extruder and the enhanced-design extruder, with examples for processes limited by torque and feed volume, along with the corresponding melt-temperature ramifications. Various system configurations will also be presented for PLA, TPS, and other biobased materials as part of pelletizing, profile, sheet, and foaming extrusion systems.