1/21/2011
Electrically controlled drug release from nanostructured polypyrrole coated on titanium
(# 085101) Nanotechnology 22 #8 (2010)
Sirivisoot, Pareta and Webster of Brown Universit, Rhode Island deposited antibiotics (penicillin/streptomycin, P/S) or an anti-inflammatory drug (dexamethasone, Dex), termed PPy[P/S] or PPy[Dex] in PPy on titanium. Results from cyclic voltammetry showed that 80% of the drugs were released on demand when sweep voltages were applied for five cycles at a scan rate of 0.1  V s− 1.  Results showed that PPy[Dex] enhanced osteoblast adhesion after 4 h of culture compared to plain Ti. PPy–Ti (with or without anionic drug doping) inhibited fibroblast adhesion compared to plain Ti. These in vitro results confirmed that electrodeposited PPy[P/S] and PPy[Dex] can release drugs on demand to potentially fight bacterial infection, reduce inflammation, promote bone growth or reduce fibroblast functions.  (RDC 1/21/2011)