Preparation and Characterization of Molecularly Imprinted Polymeric Nanoparticles for Atrial Natriuretic Peptide (ANP)
( 4423–4429)Advanced Functional Materials 21  #23 (2011)
Wang et al of the University of South Florida and the VA Hospital, Florida, prepared the nanoparticles y precipitation polymerization using NH2–SLRRSS–CONH2, which is a short peptide from ANP, as a template, methacrylic acid and N-isopropylacrylamide as functional monomers, and bis-acrylamide as a crosslinker.  The result is nanoparticles with a high affinity and selectivity for the cardiac hormone atrial natriuretic peptide and can be used as a synthetic antibody for modulating atrial natriuretic peptide - natriuretic peptide receptor A  signaling in cancers.  (RDC 12/6/2011)