Interpenetrating Network Drug Release Systems

Interpenetralting networks can be effective drug release systems.  (RDC 1/10/2010)

Recent Journal Articles

1/7/2011
Preparation, properties, and drug release of thermo- and pH-sensitive poly((2-dimethylamino)ethyl methacrylate)/poly(N,N-diethylacrylamide) semi-IPN hydrogels
(1523-1534) Journal of Materials Science 46 #5 (2011)
Zhang et al, China showed that the interior morphology by scanning electron microscopy is an interconnected porous network structures.  The semi-IPN hydrogels showed fast swelling and deswelling rates in response to temperature and pH change. These results suggest that the stimuli semi-IPN hydrogel have potential application as intelligent drug carriers.  (RDC 1/12/2011)

Synthesis and Characterization of Sodium Alginate-g-2-Hydroxyethyl Methacrylate Interpenetrating Beads for Controlled Release of Acebutolol Hydrochloride
(25-37) Designed Monomers and Polymers 14 #1 (2011)
Yerriswamy et al of Krishnadevaraya University, India  prepared the beads by free-radical polymerization.  Poly(HEMA)-grafted-sodium alginate beads were produced by solvent evaporation using glutaraldehyde as the cross-linking agent.  This resulted in a mean particle size of 100 μm.  Drug was released in a controlled manner up to 12 h.  (RDC 1/6/2011)