Microholes that allow a fluid exchange between the top and bottom surfaces of the microelement array are often needed. They typically are designed to penetrate the stratum corneum of animal skin, or to penetrate some other type of membrane. Once the penetration has been accomplished, a fluid (e.g., liquid drugs) can be dispensed into the body from a reservoir in the microstructure, or in the reverse direction, a body fluid can be sampled into such a reservoir in the microstructure. The proper size and shape of the microholes depend upon many factors, and for some applications (e.g., drug delivery or body fluid sampling through human skin), several different sizes, and especially shapes, are needed. (Sherman and Gartstein, US Patent 7,572,405, 8/11/2009) 

Recent US Patents

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Editor's Notes

As the literature is reviewed, and items of interest concerning this topic are found. These may be added in an abbreviated form with the reference. Readers and contributors are invited to add their own notes. Contributors may add them directly and other readers can simply send their notes to the editor, Roger Corneliussen at rcorneliussen@4spe.org. He may edit and add them to this page at his discretion.