2/4/2011
Poly(sebacic acid-co-ricinoleic acid) biodegradable carrier for delivery of tamsulosin hydrochloride
(114–118)Polymers for Advanced Technologies 22 #1 (2011)
Havivi, Farber and Domb of the The Hebrew University of Jerusalem, Israel  synthesized polyesteranhydrides by the transesterification of ricinoleic acid and sebacic acid followed by anhydride polymerization.  Polymers containing 70% ricinoleic acid are liquid at body temperature and semisolid at room temperature.  It was found that upon addition of the liquid polymer to water it solidifies to form a stable semisolid polymer. Tamsulosin hydrochloride (TAM), a highly selective α1A-adrenoreceptor antagonist that has been used for the treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH), was incorporated in the polymers (2–20% w/w) and its release in buffer solution was monitored. TAM was released for over 24 days while the polymer carrier was being degraded. To conclude, Poly(sebacic acid-co-ricinoleic-acid) containing ≥ 70% ricinoleic acid are injectable biodegradable polymers and are suitable candidates for the delivery of TAM for long acting therapy.  (RDC 2/4/2011)