Synthesis and biocompatibility of a novel silicone hydrogel containing phosphorylcholine
(1795-1803)  European Polymer Journal 47  #9 (2011)
Li, Wang and Xin of East China University of Science and Technology, China, synthesized poly (methyl methacrylate-co-2-methacryloyloxyethyl phosphorylcholine-co-tris(trimethylsiloxy)-3-methacryloxypropylsilane) terpolymer (PMMT).  Poly methyl methacrylate (PMMA) and poly (methyl methacrylate-co-tris (trimethylsiloxy)-3-methacryloxypropylsilane) (PMT) were also synthesized to compare with PMMT. Protein adsorption measurement showed that for PMMT-2 membrane (MPC: 16.6 mol%), the amount of adsorbed proteins was decreased by 75.3% and 76.8% compared with PMMA and PMT membranes, respectively.  SEM pictures showed clearly that PMMT films suppressed the adhesion of platelets. It was concluded that the novel silicone hydrogel containing MPC unit was an effective candidate material for making biomaterials, particularly for contact lenses.  (RDC 8/22/2011)