Vascular Tissue Engineering
“Cardiovascular disease is the leading cause of mortality in the USA. The limited availability of healthy autologous vessels for bypass grafting procedures has led to the fabrication of prosthetic vascular conduits. While synthetic polymers have been extensively studied as substitutes in vascular engineering, they fall short of meeting the biological challenges at the blood–material interface. Various tissue engineering strategies have emerged to address these flaws and increase long-term patency of vascular grafts. Vascular cell seeding of scaffolds and the design of bioactive polymers for in situ arterial regeneration have yielded promising results.”(Ravi and Chaikof, “Biomaterials for vascular tissue engineering”, 3/5/2011)
Applications
Medicine
Tissue Engineering
Vascular Implants
Review Articles
2/25/2011
Application of Chitosan-Based Biomaterials for Blood Vessel Regeneration
(138–146)Macromolecular Symposia 297 #1 (2010)
Deng et al of the University of Ottawa,, Canada reviewed chitosan-based materials for tissue engineered blood vessels, and protein, gene and cell vectors for angiogenic therapy. (RDC 2/25/2011)