Wound Healing /Tissue Repair
“Wound healing, or wound repair, is an intricate process in which the skin (or another organ) repairs itself after injury. In normal skin, the epidermis (outermost layer) and dermis (inner or deeper layer) exists in a steady-state equilibrium, forming a protective barrier against the external environment. Once the protective barrier is broken, the normal (physiologic) process of wound healing is immediately set in motion. The classic model of wound healing is divided into three or four sequential, yet overlapping, phases: (1) hemostasis (not considered a phase by some authors), (2) inflammatory, (3) proliferative and (4) remodeling. Upon injury to the skin, a set of complex biochemical events takes place in a closely orchestrated cascade to repair the damage. Within minutes post-injury, platelets (thrombocytes) aggregate at the injury site to form a fibrin clot. This clot acts to control active bleeding (hemostasis).”(Wikipedia, Wound Healing, 12/4/2010)
Chitosan Tissue Repair
Protein Tissue Repair
PTFE Tissue Repair
Recent Journal Articles
1/7/2010
Multifunctional gentamicin supplementation of poly(γ-glutamic acid)-based hydrogels for wound dressing application
(1057–1068)Journal of Applied Polymer Science 120 #2 (2011)
Lin et al, Taiwan developed multifunctional hydrogels composed of genipin-crosslinked biodegradable biomaterials of poly(γ-glutamic acid) and gelatin, encapsulating gentamicin to accelerate wound healing. In an in vitro study, the gentamicin incorporated in prepared hydrogels effectively inhibited target microorganisms and produced a higher expression of Type I collagen in fibroblast cells. (RDC 1/10/2011)